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|Пакет:||Небезрассудные пути упаковки для гарантированного пропуска таможен||Использование:||фармацевтический материал|
|Точка плавления:||264° к||Внешний вид:||Белый кристаллический порошок|
Anti Estrogen Steroids Powder 99% Purity Trilostane for Breast Cancer Treatment / CAS 13647-35-3
CAS Registry Number: 13647-35-3
Einecs No: 237-133-0
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Appearance: White crystalline powder
Manufacturer: Yuan Cheng
Molecular Weight: 329.4333
Molecular Formula: C20H27NO3
Melting point: 264° C
Boiling point: 497.8° C at 760 mmHg
Refractive index: 1.61
Flash point: 254.8° C
Vapour Pressur: 5.39E-12mmHg at 25° C
Lead time: 1-2 days upon receipt of payment
Delivery Term: Products below 200Kg by air; Over 200Kg by ship
Delivery Time: Average 6 days by air; 15 days by ship
Usage: Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase,
make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome
(hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum
Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase,
which plays a role in adrenal steroid biosynthesis. Investigators believe
that Arg195 in 3β-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of
3β-HSD, but not
3βHSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular
production oin LNCaPFGC prostate cancer cells and inhibiting cortisol biosynthesis in the human
adrenal gland. This product serves as a useful tool in steroid biosynthesis research.
Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.
Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5, 4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
|Test Item||Analysis Specification||Result|
|Description||White to off-white power||Conforms|
|Loss on drying||≤0.5%||0.26%|
|Residue on ignition||≤0.1%||0.04%|
|Specific optional rotation||+137°~ +139°||+138.8°|
Conform to Company Standard.
1. Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible. including cortisol. Inhibiting this enzyme inhibits the production of cortisol.
2. Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxy steroids dehydrogenase/delta 5,4 keto steroids isomerase, thus blocking synthesis of adrenal steroids. Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
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